This case study was created by the following OIRC hubs:
Parkinson’s Disease (PD), the second most common neurodegenerative disease globally, is associated with significant motor and non-motor symptoms. Gastrointestinal (GI) symptoms, particularly constipation, are highly prevalent and emerging evidence highlights the role of gut microbiome dysbiosis and nutritional deficiencies in PD progression, yet dietary interventions remain underexplored. The Food4PD project aimed to address this gap. In collaboration with the industry partner, ABC Nutritionals, the team developed a bespoke functional drink (enriched with chicory inulin, B-vitamins, and vitamin D) tailored to address the needs of people living with PD. The effectiveness of this functional drink in alleviating constipation, improving nutritional status, and microbiome profiles in people living with PD was then evaluated through a randomised controlled trial. The project also enabled the research to team to establish stronger working relationships with the Parkinson’s community, including charities, support groups, and individuals living with the condition. These interactions have provided us with valuable insights into the lived experiences of people living with PD, ensuring that the project and all follow-on activities remain aligned with the needs and priorities of people living with PD. Building on the success of Food4PD, the team has secured additional funding, through the NILAB BBSRC-funded doctoral training programme, to further explore the role of nutrition, and its interactions with other biological and environmental risk factors, in the development and management of PD using AI approaches. We were also successful in obtaining additional funding from the OIRC INFORM Hub to produce an impact report that explores the potential beneficial effects (both health and economic) of implementing prebiotic supplementation in people with PD on a UK-wide scale. Overall, this project and related follow-on activities are aimed at increasing our understanding of the role of nutrition in PD and ultimately improving the quality of life for people living with PD.
"This funding was instrumental in establishing a multidisciplinary team dedicated to improving the lives of people with living with Parkinson’s disease, enabling us to build a strong track record and to partner with the foodindustry to develop high-quality food product aimed at alleviating constipation and improving nutritional status in people living with PD. The project has also helped raise awareness about the nutritional issues faced by people living with PD and established the foundation for further research in this area."
